At this point, nearly every fantasy league is on to the championship game, so start 'em, sit 'em decisions have never been more important. There are plenty of new RB2s in our rankings, as injuries to Clyde Edwards-Helaire, Cam Akers, Raheem Mostert, Ronald Jones, and more are having an impact on depth. That will impact decisions at the flex spot, as waiver-wire pickups and replacements for those backs may now be in play. Our Week 16 fantasy flex rankings can help you decide between newfound sleepers and matchup-based streamers.Those new RB2s will include the likes Tyler Johnson Jersey of Le'Veon Bell, Darrell Henderson, Jeff Wilson Jr., and Leonard Fournette. If you are lucky enough to own any of these players, they will be worth starting, with Fournette looking like a particularly solid play in an elite matchup against the Lions. Beyond those players, there is still tons of receiver depth, per usual, but some players in great matchups will move up a bit ahead of what some may consider the bigger names at the position.WEEK 16 DFS TOURNAMENT LINEUPS: | Speaking of great matchups, they will be the biggest tiebreakers this week for fantasy owners making difficult lineup decisions. For running backs, the Bengals (@ Texans), Buccaneers (@ Lions), Dolphins (@ Raiders), and Bears (@ Jaguars) all stand out as having good matchups. That will provide a boost to the likes of Giovani Bernard, Fournette, Myles Gaskin/Salvon Ahmed, and David Montgomery.At WR, the best matchups include the Rams (@ Seahawks), Chiefs (vs. Falcons), Eagles (@ Cowboys), and Saints (vs. Vikings). Aside from the usual top options for those teams, more opportunities will be opened up for the likes of Josh Reynolds, Mecole Hardman, Jalen Reagor, Greg Ward, and Emmanuel Sanders to be considered for the flex spot thanks to their excellent matchups.WEEK 16 STANDARD RANKINGS: | | | | | There are a couple of ways to approach the flex spot, and it's all about knowing what your lineup needs more of. If you need a player with a high ceiling, usually a WR is the way to go. There are a lot of big-play options at that spot, so trusting Brooklyn Nets Jeresy somebody like Darnell Mooney (@ Jaguars) could pan out. If you need a player with a higher ceiling, a running back like Frank Gore (vs. Browns), who is going to get a high volume of touches, is the right option to trust.As always, once you've decided on your final lineup, make sure your latest-starting player is plugged into the flex spot. That gives you some flexibility in case a last-minute injury or COVID i sue causes that player to be ruled out.WEEK 16 DFS CASH LINEUPS: |Without further ado, here are our Week 16 flex rankings.WEEK 16 PPR RANKINGS: | | | | | MORE WEEK 16 DFS: | | RankPlayer1Derrick Henry, RB, Titans @ Garrett Temple Jersey Packers2Aaron Jones, RB, Packers vs. Titans3Nick Chubb, RB, Browns @ Jets4David Montgomery, RB, Bears @ Jaguars5Alvin Kamara, RB, Saints vs. Vikings6Tyreek Hill, WR, Chiefs vs. Falcons7Davante Adams, WR, Packers vs. Titans8Allen Robinson, WR, Bears @ Jaguars9Dalvin Cook, RB, Vikings @ Saints10Austin Ekeler, RB, Chargers vs. Broncos11Miles Sanders, RB, Eagles @ Cowboys12DeAndre Hopkins, WR, Cardinals vs. 49ers13Stefon Diggs, WR, Bills @ Patriots14Mike Evans, WR, Buccaneers @ Lions15Josh Jacobs, RB, Raiders vs. Dolphins16Melvin Gordon, RB, Broncos @ Chargers17Chris Godwin, WR, Buccaneers @ Lions18Calvin Ridley, WR, Falcons @ Chiefs19A.J. Brown, WR, Titans @ Packers20David Johnson, RB, Texans vs. Bengals21Brandon Aiyuk, WR, 49ers @ Cardinals22Cooper Kupp, WR, Rams @ Seahawks23Robert Woods, WR, Rams @ Seahawks24Travis Kelce, TE, Chiefs vs. Falcons25Myles Gaskin, RB, Dolphins @ Raiders26Antonio Gibson, RB, Washington vs. Panthers27Giovani Bernard, RB, Bengals @ Texans28Leonard Fournette, RB, Buccaneers @ Lions29Tee Higgins, WR, Bengals @ Texans30Amari Cooper, WR, Cowboys vs. Eagles31Darren Waller, TE, Raiders vs. Dolphins32Sony Michel, RB, Patriots vs. Bills33Noah Fant, TE, Broncos @ Chargers34Adam Thielen Andre Roberson Jersey , WR, Vikings @ Saints35DK Metcalf, WR, Seahawks vs. Rams36Justin Jefferson, WR, Vikings @ Saints37Jonathan Taylor, RB, Colts @ Steelers38Mike Davis, RB, Panthers @ Washington39Marvin Jones, WR, Lions vs. Buccaneers40Emmanuel Sanders, WR, Saints vs. Vikings41Kareem Hunt, RB, Browns @ Jets42Antonio Brown, WR, Buccaneers @ Lions43Brandin Cooks, WR, Texans vs. Bengals44Chris Carson, RB, Seahawks vs. Rams45Le'Veon Bell, RB, Chiefs vs. Falcons46Jeff Wilson Jr., RB, 49ers @ Cardinals47Kenyan Drake, RB, Cardinals vs. 49ers48Salvon Ahmed, RB, Dolphins @ Raiders49Tyler Lockett, WR, Seahawks vs. Rams50Keke Coutee, WR, Texans vs. Bengals51Jamison Crowder, WR, Jets vs. Browns52T.J. Hockenson, TE, Lions vs. Buccaneers53T.Y. Hilton, WR, Colts @ Steelers54JK Dobbins, RB, Ravens vs. Giants55D'Andre Swift, RB, Lions vs. Buccaneers56JuJu Smith-Schuster, WR, Steelers vs. Colts57CeeDee Lamb, WR, Cowboys vs. Eagles58Corey Davis, WR, Titans @ Packers59J.D. McKi sic, RB, Washington vs. Panthers60Ezekiel Elliott, RB, Cowboys vs. Eagles61Wayne Gallman, RB, Giants @ Ravens62James Conner, RB, Steelers vs. Colts63D.J. Moore, WR, Panthers @ Washington64Robby Anderson, WR, Panthers @ Washington65Jalen Reagor, WR, Eagles @ Cowboys66Mark Andrews, TE, Ravens vs. Giants67George Kittle, TE, 49ers @ Cardinals68Robert Tonyan, TE, Packers vs. Titans69Darrell Henderson, RB, Rams @ Seahawks70Ru sell Gage, WR, Falcons @ Chiefs71Nelson Agholor, WR, Raiders vs. Dolphins72Mike Williams, WR, Chargers vs. Broncos73Mike Gesicki, TE, Dolphins @ Raiders74Chase Claypool, WR, Steelers vs. Colts75Diontae Johnson, WR, Steelers vs. Colts76Sammy Watkins, WR, Chiefs vs. Falcons77Tim Patrick, WR, Broncos @ Chargers78Marquise Brown, WR, Ravens vs. Giants79Logan Thomas, TE, Washington vs. Panthers80Devin Singletary, RB, Bills @ Patriots81Zack Mo s, RB, Bills @ Patriots82Curtis Samuel, WR, Panthers @ Washington83Cole Beasley, WR, Bills @ Patriots84Jakeem Grant, WR, Dolphins @ Raiders85Marvin Hall, WR, Browns @ Jets86Darnell Mooney, WR, Bears @ Jaguars87Frank Gore, RB, Jets vs. Browns88Tyron Johnson, WR, Chargers vs. Broncos89Tony Pollard, RB, Cowboys vs. Eagles90Lynn Bowden, WR, Dolphins @ Raiders91Marquez Callaway, WR, Saints vs. Vikings92Rob Gronkowski, TE, Buccaneers @ Lions93Marquez Valdes-Scantling, WR, Packers vs. Titans94DJ Chark, WR, Jaguars vs. Bears95Sterling Shepard, WR, Giants @ Ravens96Allen Lazard, WR, Packers vs. Titans97Dallas Goedert, TE, Eagles @ Cowboys98Gus Edwards, RB, Ravens vs. Giants99Kendrick Bourne, WR, 49ers @ Cardinals100Jerry Jeudy, WR, Broncos @ Chargers101Jakobi Meyers, WR, Patriots vs. Bills102John Brown, WR, Bills @ Patriots103Josh Reynolds Reggie Perry Jersey , WR, Rams @ Seahawks104Austin Hooper, TE, Browns @ Jets105Malcolm Brown, RB, Rams @ Seahawks106AJ Dillon, RB, Packers vs. Titans107A.J. Green, WR, Bengals @ Texans108Cam Sims, WR, Washington vs. Panthers109Isaiah Wright, WR, Washington vs. Panthers110Breshad